30123-17-2
- Product Name：Tianeptine sodium salt
- Molecular Formula：C21H24ClN2NaO4S
- Purity：99%
- Molecular Weight：
Product Details
Appearance:white to yellowish powder
High Quality High Purity 99% Tianeptine sodium salt 30123-17-2 In Medicine manufacturer, Good Supplier, in stock, In Bulk Supply
- Molecular Formula:C21H24ClN2NaO4S
- Molecular Weight:458.93
- Appearance/Colour:white to yellowish powder
- Melting Point:180 °C
- Boiling Point:609.2 °C at 760 mmHg
- Flash Point:322.2 °C
- PSA：97.92000
- Density:1.38 g/cm3
- LogP:4.39460
99% Tianeptine sodium salt 30123-17-2 Usage
Tianeptine sodium salt (TSS) is a facilitator of serotonin and norepinephrine reuptake. Tianeptine sodium salt is an opioid, atypical antidepressant, and neurorestorative agent. It's often sold as a salt, such as its sodium or sulfate salt. Tianeptine sodium salt is used in analytical forensic applications and as a research tool. However, it has also been associated with abuse, overdose, and death. Its opioid-like actions can trigger dopamine release, which can cause euphoria-inducing effects.
InChI:InChI=1/C21H25ClN2O4S.Na/c1-24-18-9-6-5-8-16(18)21(23-13-7-3-2-4-10-20(25)26)17-12-11-15(22)14-19(17)29(24,27)28;/h5-6,8-9,11-12,14,21,23H,2-4,7,10,13H2,1H3,(H,25,26);/q;+1
Tianeptine Sodium 30123-17-2 Relevant articles
Tianeptine sodium salt suppresses TNF-α-induced expression of matrix metalloproteinase-9 in human carcinoma cells via suppression of the PI3K/Akt-mediated NF-κB pathway
Rajapaksha Gedara Prasad Tharanga Jayasooriya a, Matharage Gayani Dilshara a, Yung Hyun Choi b, Sung-Kwon Moon c, Wun-Jae Kim d, Gi-Young Kim a
Environmental Toxicology and Pharmacology Volume 38, Issue 2, September 2014, Pages 502-509
Antidepressant drugs such as norfluoxetine, clomipramine, and desimpramine caused a significant decrease in cell viability by inducing mitochondrial dysfunction-mediated caspase-3 activation; however, no cytotoxic effects or changes in mitochondrial potential were observed in TSS-treated cells (Abdel-Razaq et al., 2011). To data, no studies have been published as to whether TSS regulates invasion of tumor cells. Therefore, we evaluated the effects of TSS on MMP-9 expression and invasion in TNF-α-stimulated prostate, bladder, and breast carcinoma cells. Taken together, TSS downregulates TNF-α-induced MMP-9 expression and invasion by suppressing phosphatidyl-inositol 3 kinase (PI3K)/Akt-mediated NF-κB activation.
In Vitro–In Vivo Correlation of Tianeptine Sodium Sustained-Release Dual-Layer Tablets
YJ Lee, JE Kim
Molecules 2022, 27(9), 2828
IVIVC was established according to the size of the tianeptine sodium granules, which is the purpose of this study, and was used to predict in vivo pharmacokinetics from the formulation composition. This approach may be useful for determining optimal formulation compositions to achieve the desired pharmacokinetics when developing new formulations.
Respiratory effects of the atypical tricyclic antidepressant tianeptine in human models of opioid-induced respiratory depression
Hyke Algera, M.D.; Rutger van der Schrier, M.D.; David Cavalla, Ph.D.; Monique van Velzen, Ph.D.; Margot Roozekrans, M.D., Ph.D.; Alison McMorn, Ph.D.; Michael Snape, Ph.D.; Joseph P. Horrigan, M.D.; Stuart Evans, M.A.; Bernard Kiernan, Ph.D.; Elise Sarton, M.D., Ph.D.; Erik Olofsen, Ph.D.; Marieke Niesters, M.D., Ph.D.; Albert Dahan, M.D., Ph.D.
Anesthesiology October 2022, Vol. 137, 446–458.
For studies 2a and 2b, a sterile tianeptine sodium intravenous formulation (sodium; 7-[(3-chloro-6-methyl-5,5-dioxo-11Hbenzo[c][2,1] benzothiazepin-11-yl)amino]heptanoate; 1 mg/ml) was developed by AMO Pharma Ltd. Tianeptine is a drug with two pKa values.
Analysis of Tianeptine in Dietary Supplements
Jared T. Seale 1,Emily A. Garden 2,John M. T. French 3 andOwen M. McDougal 1
Nutraceuticals 2023, 3(3), 481-488;
For Tianaa™ analysis, the gradient elution started at 15% solvent B and increased to 50% solvent B over 10 min. After 10 min, the solvent composition was returned to 15% solvent B between minutes 10 and 15. The electrospray ionization source was operated under the following conditions: positive ion-mode, 4000 to −4000 V between capillaries, 7.0 L/min N2 drying gas at 300 °C and nebulizer pressure of 15 psi. Tianeptine was quantified using standard curve using a tianeptine sodium salt hydrate (>98% purity, CAS RN 30123-17-2) purchased from TCI America diode array detector (DAD) measuring absorbance at 220 nm.
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