171596-29-5
- Product Name：Tadalafil
- Molecular Formula：C22H19N3O4
- Purity：99%
- Molecular Weight：
Product Details
Appearance:white powder
Throughput:10000|Kilogram|Year
pd_productuse: Male Sex Hormones
Delivery Time:3days
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High Quality Raw materials of health products Tadalafil 171596-29-5 In Medicine Good Supplier
- Molecular Formula:C22H19N3O4
- Molecular Weight:389.411
- Appearance/Colour:white to off-white cyrstalline solid
- Vapor Pressure:5.29E-13mmHg at 25°C
- Melting Point:298-300 °C
- Refractive Index:1.705
- Boiling Point:679.1 °C at 760 mmHg
- PKA:16.68±0.40(Predicted)
- Flash Point:364.5 °C
- PSA：74.87000
- Density:1.51 g/cm3
- LogP:2.08710
Tadalafil 171596-29-5 Usage
Tadalafil (TDF) was originally developed as a treatment for erectile dysfunction in addition to other PDE5 inhibitors: sildenafil, vardenafil, and avanafil. The chemical formula of Tadalafil is C22H19N3O4 which containing 22 Carbon atoms,19 Hydrogen atoms,3 Nitrogen atoms and 4 Oxygen atoms,and the molecular weight of Tadalafil is 389.411.
Tadalafil is a highly selective inhibitor of PDE5A, it prevented glomerular injury in a rat model of kidney injury.
InChI:InChI=1/C22H23N3O3/c1-24-8-9-25-17(22(24)26)11-15-14-4-2-3-5-16(14)23-20(15)21(25)13-6-7-18-19(10-13)28-12-27-18/h2-7,10,15,17,20-21,23H,8-9,11-12H2,1H3/t15?,17-,20?,21-/m1/s1
171596-29-5 Relevant articles
Development of validated methods for the simultaneous quantification of Finasteride and Tadalafil in newly launched FDA-approved therapeutic combination: greenness assessment using AGP, analytical eco-scale, and GAPI tools
Ahmed K. Kammoun, Maan T. Khayata, Ahmad J. Almalkia and Rasha M. Youssef
RSC Adv., 2023, 13, 11817-11825
Pharmaceutical grade of Finasteride and Tadalafil were supplied from Sigma-Aldrich (GmbH, Steinheim, Germany). The main advantage of the proposed derivative spectrophotometric method in comparison with the reported method is the greenness as it used ethanol instead of methanol.
Efficacy of tadalafil and l-arginine combination therapy compared with tadalafil-only for the treatment of erectile dysfunction: A systematic review and meta-analysis
Donny Austine Wibisono , Furqan Hidayatullah , Fikri Rizaldi , Tarmono Djojodimedjo
Paragraph 0015; 0041-0042, (2022/03/27)
The combination of tadalafil and L-arginine can improve erectile function and testosterone levels. A significant increase in IIEF-5 score and testosterone level is observed in patients with ED who received combination therapy of tadalafil and L-arginine compared to tadalafil monotherapy.
171596-29-5 Process route
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- 171489-03-5
(6R,12aR)-6-(3,4-dihydroxyphenyl)-2-methyl-2,3,6,7,12,12a-hexahydropyrazino[1',2'-1,6]-pyrido[3,4-b]indole-1,4-dione
-
- 74-95-3
1,1-dibromomethane
-
- 171596-29-5
(6R,12aR)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)-pyrazino[2',1':6,1]pyrido[3,4-b]indole-1,4-dione
| Conditions | Yield |
|---|---|
|
With sodium hydroxide; In N,N-dimethyl-formamide; at 60 ℃; for 6h;
|
95% |
|
With caesium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 8h;
|
93% |
|
With caesium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 8h;
|
93% |
|
With caesium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 8h;
|
93% |
-
- 1224724-00-8
(1R,3R)-methyl-1,2,3,4-tetrahydro-2-(2-(benzyl(methyl)amino)acetyl)-1-(3,4-methylenedioxyphenyl)-9H-pyrido[3,4-b]indole-3-carboxylate
-
- 171596-29-5
(6R,12aR)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)-pyrazino[2',1':6,1]pyrido[3,4-b]indole-1,4-dione
| Conditions | Yield |
|---|---|
|
With hydrogen; Raney Ni; In ISOPROPYLAMIDE; at 80 ℃; for 22h; under 2280.15 Torr; Product distribution / selectivity;
|
94% |
171596-29-5 Upstream products
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74-89-5
methylamine
-
171489-59-1
methyl (1R,3R)-1-(3,4-methylenedioxyphenyl)-2-chloroacetyl-2,3,4,9-tetrahydro-9H-pyrido[3,4-b]indol-3-carboxylate
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749864-18-4
1-benzo[1,3]dioxol-5-yl-2-{[(9H-fluoren-9-ylmethoxycarbonyl)-methyl-amino]-acetyl}-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylic acid methyl ester
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951661-81-7
(1R,3R)-1-(benzo[d][1,3]dioxol-5-yl)-2-(2-chloroacetyl)-N-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxamide
171596-29-5 Downstream products
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171596-27-3
(6R,12aS)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)-pyrazino[2',1':6,1]pyrido[3,4-b]indole-1,4-dione
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1220393-12-3
3-((2-(benzo[d][1,3]dioxole-5-carbonyl)-1H-indol-3-yl)methyl)-1-methylpiperazine-2,5-dione
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1242099-13-3
C10H12O3*C22H19N3O4
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1242099-11-1
C8H8O3*C22H19N3O4
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