16251-45-9
- Product Name：(4S,5R)-4-Methyl-5-phenyloxazolidin-2-one
- Molecular Formula：C10H11NO2
- Purity：99%min
- Molecular Weight：
Product Details
Appearance:powder
Throughput:100000|Kilogram|Year
pd_productuse:reaserch,pharmaceutical raw material
Delivery Time:3-10days
High Quality (4S,5R)-4-Methyl-5-phenyloxazolidin-2-one 16251-45-9 Export, In Stock, In Bulk Supply with the Best Price
- Molecular Formula:C10H11NO2
- Molecular Weight:177.203
- Appearance/Colour:White crystals
- Vapor Pressure:1.79E-06mmHg at 25°C
- Melting Point:121-123 °C(lit.)
- Refractive Index:1.526
- Boiling Point:395.8 °C at 760 mmHg
- PKA:12.35±0.60(Predicted)
- Flash Point:193.2 °C
- PSA：38.33000
- Density:1.132 g/cm3
- LogP:2.18480
(4S,5R)-4-Methyl-5-phenyloxazolidin-2-one 16251-45-9 Usage
(4S,5R)-4-Methyl-5-phenyloxazolidin-2-one is white crystals chemical compound. (4S,5R)-(-)-4-Methyl-5-phenyl-2-oxazolidinone may be used to synthesize (4S,5R)-N-tert-butyloxycarbonyl)-4-methyl-5-carboxy-2-oxazolidinone and (+)-pumiliotoxin B.
InChI:InChI=1/C10H11NO2/c1-7-9(13-10(12)11-7)8-5-3-2-4-6-8/h2-7,9H,1H3,(H,11,12)/t7-,9-/m0/s1
16251-45-9 Relevant articles
Carbon dioxide as a carbonylating agent in the synthesis of 2-oxazolidinones, 2-oxazinones, and cyclic ureas: Scope and limitations
Jairo Paz, Carlos Pérez-Balado, Beatriz Iglesias, and Luis Muñoz
J. Org. Chem. 2010, 75, 9, 3037–3046
Carbon dioxide can be used as a convenient carbonylating agent in the synthesis of 2-oxazolidinones, 2-oxazinones, and cyclic ureas. The expected 4-methyl-5-phenyloxazolidin-2-one 7i was isolated in 78% yield (Table 1, entry 1). Encouraged by this preliminary result, we directed our attention toward the key role of …
A refined synthesis of enantiomerically pure 2-aminocyclobutanecarboxylic acids
V Declerck, DJ Aitken
Amino Acids, 2011
The synthesis of enantiomerically pure 2-aminocyclobutanecarboxylic acids has been refined to improve both the efficiency and the simplicity. Solution of (4S,5R)-4-methyl-5-phenyloxazolidin-2-one 12 (2.21 g, 12.5 mmol, 1 equiv.) in THF (60 mL) was treated with n-BuLi (1.6 M solution in hexanes, 7.81 mL, 12.5 mmol, 1 …
16251-45-9 Process route
-
- 39663-75-7
(+/-)-cis-4-methyl-5-phenyloxazolidin-2-one
-
- 77943-39-6
4-methyl-5-phenyloxazolidin-2-one
-
- 16251-45-9,17097-67-5,28044-22-6,28044-23-7,39663-75-7,54418-69-8,77943-39-6,125133-96-2,149055-02-7
(4S,5R)-4-methyl-5-phenyl-oxazolidin-2-one
| Conditions | Yield |
|---|---|
|
With molecule imprinted polymer; In acetonitrile; at 25 ℃; pH=7; Resolution of racemate; aq. phosphate buffer;
|
|
|
With Pirkle-type column (Whelk-O-1 CSP); In hexane; isopropyl alcohol; Reagent/catalyst; Resolution of racemate;
|
-
- 899426-20-1
(4S,5R,2'R,3'R,1''R)-3-[3'-(4-chlorophenyl)-3'-hydroxy-2'-(1''-methylsulfanyl-1''-phenylmethyl)propionyl]-4-methyl-5-phenyloxazolidin-2-one
-
- 75-08-1
ethanethiol
-
- 16251-45-9,17097-67-5,28044-22-6,28044-23-7,39663-75-7,54418-69-8,77943-39-6,125133-96-2,149055-02-7
(4S,5R)-4-methyl-5-phenyl-oxazolidin-2-one
-
- 36056-25-4
S-ethyl 3-(ethylsulfanyl)-3phenylpropanethioate
-
- 104-88-1
4-chlorobenzaldehyde
| Conditions | Yield |
|---|---|
|
With n-butyllithium; In tetrahydrofuran; at 0 ℃; for 0.333333h;
|
33 mg 21 mg 11 mg |
16251-45-9 Upstream products
-
36482-33-4
(2RS,3SR)-3-hydroxy-2-methyl-3-phenyl-propionic acid hydrazide
-
48115-38-4
norepinephrine
-
105-58-8
Diethyl carbonate
-
497-19-8
sodium carbonate
16251-45-9 Downstream products
-
54680-46-5
norephedrine
-
42746-64-5
4r-methyl-3-nitroso-5t-phenyl-oxazolidin-2-one
-
4830-43-7
(1RS,2RS)-2-isopropylamino-1-phenyl-propan-1-ol
-
130258-52-5
(4S,5R)-3-<(R)-5,6-(Isopropylidenedioxy)hexanoyl>-4-methyl-5-phenyl-1,3-oxazolidin-2-one
Relevant Products
-
Cyclopropane, isocyanato- 4747-72-2CAS：4747-72-2
-
Gentamycin sulfateCAS：1405-41-0
-
Acteoside/VerbascosideCAS：61276-17-3
