Product Details
Appearance:solid
Lidocaine is a local anesthetic, also known as Xylocaine, in recent years it has been replaced procaine, widely used in local infiltration anesthesia in cosmetic plastic surgery, it can block the nerve excitability and conduction by inhibiting the sodium channels of nerve cell membrane.
Lidocaine Good Supplier In China
- Molecular Formula:C14H22N2O
- Molecular Weight:234.341
- Appearance/Colour:solid
- Vapor Pressure:4.28E-05mmHg at 25°C
- Melting Point:66-69 °C
- Refractive Index:1.5110 (estimate)
- Boiling Point:350.8 °C at 760 mmHg
- PKA:pKa 7.88(H2O)(Approximate)
- Flash Point:166 °C
- PSA：32.34000
- Density:1.026 g/cm3
- LogP:2.65670
Hot Sale 137-58-6 in stock
Lidocaine is an Anesthetic (local); antiarrhythmic (class IB). Long-acting, membrane stabilizing agent against ventricular arrhythmia. Besides its use as a local and topical anesthetic agent, lidocaine is used to treat ventricular arrhythmias, principally ventricular tachycardia and ventricular premature complexes in all species. Lidocaineis primarily metabolized by de-ethylation of the tertiary nitrogento form monoethylglycinexylidide (MEGX). At lowlidocaine concentrations, CYP1A2 is the enzyme responsiblefor most MEGX formation. At high lidocaine concentrations,both CYP1A2 and CYP3A4 are responsible for the formationof MEGX.
Definition
ChEBI: Lidocaine is the monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline. It has a role as a local anaesthetic, an anti-arrhythmia drug, an environmental contaminant, a xenobiotic and a drug allergen. It is a monocarboxylic acid amide, a tertiary amino compound and a member of benzenes. It derives from a glycinamide.
InChI:InChI=1/C14H22N2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4/h7-9H,5-6,10H2,1-4H3,(H,15,17)/p+1
137-58-6 Relevant articles
LidocAine Versus Opioids In MyocarDial infarction: the AVOID-2 randomized controlled trial
Himawan Fernando, Ziad Nehme, Catherine Milne, Jessica O’Brien, Stephen Bernard, Michael Stephenson, Paul S Myles, Jeffrey Lefkovits, Karlheinz Peter, Angela Brennan, Diem Dinh, Emily Andrew, Andrew J Taylor, Karen Smith, Dion Stub
,European Heart Journal. Acute Cardiovascular Care, Volume 12, Issue 1, January 2023, Pages 2–11
IV Lidocaine did not meet the criteria for non-inferiority with lower prehospital pain reduction than fentanyl but was safe and better tolerated as analgesia in ST-elevation myocardial infarction (STEMI). Future trials testing non-opioid analgesics in STEMI and whether opioid avoidance improves clinical outcomes are needed.
Multicomponent Synthesis of Lidocaine at Room Temperature
Michelle Lee, Nathan J. Vosburg, Emily A. Shimizu, Manuel A. Rentería-Gómez, Rocío Gámez-Montaño, and David A. Vosburg
Journal of Chemical Education 2022, 99, 6, 2399–2402
Students also evaluated multiple lidocaine synthesis procedures using green chemistry principles and explored the reaction mechanisms of both traditional (N-acylation followed by N-alkylation) and multicomponent lidocaine syntheses.
Lidocaine enemas for intractable distal ulcerative colitis (IDUC): Efficacy and safety
-
《Gastroenterology》Saibil，F.G, (1998)
We report a 62-year-old patient with alcoholic Liver disease who presented with Escherichia coli bacteremia and septic arthritis in a previously fractured ankle. There are scarce reports of infectious arthritis in cirrhotic patients, but this is the first report of arthritis after a primary enteric bacteremia.
137-58-6 Process route
-
- 178421-96-0
C14H22N2O*C56H98O35
-
- 137-58-6
2-diethylamino-N-(2,6-dimethylphenyl)-acetamide
-
- 51166-71-3
heptakis(2,6-di-O-methyl)cyclomaltoheptaose
| Conditions | Yield |
|---|---|
|
With pluronic copolymer F290; In water; at 25 ℃; Reagent/catalyst; Equilibrium constant;
|
-
![[(2,6-dimethylphenylcarbamoyl)methyl]diethyl-(4-phosphonooxybenzyl)ammonium trifluoroacetate disodium salt](/upload/2023/1/7e281d3e-7b0c-4698-9b70-d4986458edee.png)
-
[(2,6-dimethylphenylcarbamoyl)methyl]diethyl-(4-phosphonooxybenzyl)ammonium trifluoroacetate disodium salt
-
- 623-05-2
(4-hydroxyphenyl)methanol
-
- 137-58-6
2-diethylamino-N-(2,6-dimethylphenyl)-acetamide
| Conditions | Yield |
|---|---|
|
With alkaline phosphatase; In water; at 37 ℃; for 6h; pH=7.4; Enzyme kinetics; Enzymatic reaction;
|
137-58-6 Upstream products
-
109-89-7
diethylamine
-
1131-01-7
2-chloro-N-(2,6-dimethylphenyl)acetamide
-
3734-33-6
denatonium benzoate
-
87-62-7
2,6-dimethylaniline
137-58-6 Downstream products
-
24003-58-5
Lidocaine N-ethyl bromide
-
5369-03-9
QX-314
-
2903-45-9
lidocaine N-oxide
-
75889-35-9
2-Diethylamino-N-(2,6-dimethyl-phenyl)-N-(2-ethoxy-ethyl)-acetamide
Relevant Products
-
Cyclopropane, isocyanato- 4747-72-2CAS：4747-72-2
-
2-Bromo-4'-MethylpropiophenoneCAS：1451-82-7
-
Calcium propionate, calcium salt (2:1)CAS：4075-81-4
