1451-82-7
- Product Name：2-Bromo-4'-Methylpropiophenone
- Molecular Formula：C10H11BrO
- Purity：99%
- Molecular Weight：
Product Details
Appearance:Off-white solid
2-Bromo-4-Methylpropiophenone 1451-82-7 Manufacturers, Factory Suppliers From China, We are seeking for extensive cooperation with honest customers.
2-Bromo-4′-methylpropiophenone is usually used as the intermediate and raw material in the fine chemistry industry.
2-Bromo-4'-Methylpropiophenone 1451-82-7 superior manufacturer, factory sells
- Molecular Formula:C10H11BrO
- Molecular Weight:227.101
- Appearance/Colour:Off-white solid
- Melting Point:75-77 °C
- Boiling Point:273.205 °C at 760 mmHg
- Flash Point:58.628 °C
- PSA：17.07000
- Density:1.357 g/cm3
- LogP:2.96110
1451-82-7 Usage
2-Bromo-4'-methylpropiophenone (cas# 1451-82-7) belongs to the group of phenols, is a compound useful in organic synthesis. It employed as an important intermediate for raw material for organic synthesis, agrochemical, pharmaceutical and dyestuff field. Also used as intermediate for 4-methylmethcathinone.
1451-82-7 Relevant articles
Design, synthesis and broad-spectrum Bcr-Abl inhibitory activity of novel thiazolamide-benzamide derivatives
Liu, Juan,Huang, Honglin,Deng, Xiangping,Xiong, Runde,Cao, Xuan,Tang, Guotao,Wu, Xin,Xu, Shiyu,Peng, Junmei
, p. 2092 - 2101 (2019)
Bcr-Abl plays an important role in the pathogenesis and development of chronic myeloid leukemia (CML). The most potent compound 3m exhibited an Abl IC50 value as low as 1.273 μM and showed inhibition to the T315I mutant with IC50 value 39.89 μM. 3m could prove to be a new promising lead compound for the further development of broad-spectrum Bcr-Abl inhibitors to overcome clinical acquired resistance.
Enantioselective Synthesis of Nitrogen-Nitrogen Biaryl Atropisomers via Copper-Catalyzed Friedel-Crafts Alkylation Reaction
Guo, Chang-Qiu,Liu, Ren-Rong,Lu, Chuan-Jun,Wang, Xiao-Mei,Xu, Qi,Zhang, De-Bing,Zhang, Peng
supporting information, p. 15005 - 15010 (2021/09/30)
Access to α,α-dihaloacetophenones through anodic C[dbnd]C bond cleavage in enaminones
Bu, Jiping,Huang, Zijun,Li, Shaoke,Ma, Xiantao,Wu, Kairui,Yang, Jiusi,Yu, Renjie,Zhang, Zhenlei
, (2021/12/20)
We have developed a method to synthesize α,α-dihaloketones under electrochemical conditions. The electrosynthesis reaction can be conveniently carried out in an undivided electrolytic cell at room temperature. In addition, various functional groups are compatible with this green protocol which can be applied simultaneously to the gram scale without significantly lower yield.
1451-82-7 Process route
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- 5337-93-9
4'-methylpropiophenone
-
- 92821-88-0,1451-82-7
2-bromo-4'-methylpropiophenone
| Conditions | Yield |
|---|---|
|
With aluminum (III) chloride; bromine; In diethyl ether; at 0 ℃;
|
96% |
|
With bromine; In hexane; water; acetic acid; ethyl acetate;
|
95% |
|
With bromine; acetic acid; at 30 ℃;
|
89% |
|
With N-Bromosuccinimide; urea-hydrogen peroxide; 1-butyl-3-methylimidazolium Tetrafluoroborate; at 60 ℃;
|
78% |
|
With bromine; In acetic acid;
|
71% |
|
With bromine; In chloroform; at 0 ℃;
|
67% |
|
With bromine; In acetic acid; at 30 ℃; for 2h;
|
54% |
|
With bromine; benzene;
|
|
|
With bromine; In diethyl ether;
|
|
|
With bromine;
|
|
|
With bromine; In acetic acid;
|
|
|
With bromine; In dichloromethane; water; at 35 ℃;
|
|
|
With bromine; In aluminium chloride; chloroform;
|
|
|
With bromine; at 0 - 20 ℃;
|
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With bromine; In dichloromethane; for 10h; Inert atmosphere;
|
6.33 g |
|
With bromine; In dichloromethane; for 10h; Inert atmosphere;
|
|
|
With bromine; In dichloromethane; at 20 ℃; for 0.5h;
|
|
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With bromine; In dichloromethane; at 20 ℃; Inert atmosphere;
|
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With bromine; In diethyl ether; at 20 ℃; Inert atmosphere;
|
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With N-Bromosuccinimide; toluene-4-sulfonic acid; In acetonitrile; at 60 ℃; for 4h;
|
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With N-Bromosuccinimide; toluene-4-sulfonic acid; In acetonitrile; Reflux;
|
|
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With copper(ll) bromide;
|
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With copper(ll) bromide; In ethanol; at 78 ℃;
|
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With bromine; In dichloromethane;
|
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With hydrogen bromide; bromine; In dichloromethane; water; at 20 ℃; for 1h;
|
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With copper(ll) bromide;
|
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With bromine; In dichloromethane;
|
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|
With N-Bromosuccinimide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; In neat (no solvent); at 27 ℃; for 24h; regioselective reaction; Irradiation;
|
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With bromine; In diethyl ether; at 20 ℃; Inert atmosphere;
|
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|
Multi-step reaction with 2 steps
1: Reflux
2: hydrogen bromide / acetonitrile / 3 h / 20 °C / Electrolysis
With hydrogen bromide; In acetonitrile;
|
-
- 1432028-75-5
3-(dimethylamino)-2-methyl-1-(p-tolyl)prop-2-en-1-one
-
- 92821-88-0,1451-82-7
2-bromo-4'-methylpropiophenone
| Conditions | Yield |
|---|---|
|
With hydrogen bromide; In acetonitrile; at 20 ℃; for 3h; Electrolysis;
|
53% |
1451-82-7 Upstream products
-
5337-93-9
4'-methylpropiophenone
-
563-76-8
α-bromopropionyl bromide
-
108-88-3
toluene
-
7726-95-6
bromine
1451-82-7 Downstream products
-
15482-26-5
2-hydroxy-1-(4-methylphenyl)propan-1-one
-
236117-38-7
2-iodo-1-(p-tolyl)propan-1-one
-
64403-76-5
2-(5-amino-2-imino-[1,3,4]thiadiazol-3-yl)-1-p-tolyl-propan-1-one
-
1451-87-2
2-methoxy-1-p-tolylpropan-1-one
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