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303-98-0

Product Name：Coenzyme Q10
Molecular Formula：C₅₉H₉₀O₄
Purity：99%
Molecular Weight：

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Product Details

Appearance:yellow-orange crystalline powder

Best price 303-98-0, Coenzyme Q10 factory sells with low price

Molecular Formula:C59H90O4
Molecular Weight:863.361
Appearance/Colour:yellow-orange crystalline powder
Vapor Pressure:1.23E-30mmHg at 25°C
Melting Point:49-51 °C
Refractive Index:1.525
Boiling Point:869 °C at 760 mmHg
Flash Point:324.5 °C
PSA：52.60000
Density:0.97 g/cm³
LogP:17.85390

303-98-0 Usage

Coenzyme Q, also known as ubiquinone and marketed as CoQ10, is a quinone that is found throughout the human body in cell membranes, primarily in mitochondrial membranes, with the highest levels in the heart, lungs, liver, kidneys, spleen, pancreas, and adrenal glands. It is well known that coenzyme Q10 (CoQ10) has important antioxidant properties. Found in animal organs and yeast. It is a strong antioxidant and acts as an essential enzyme catalyst in mitochondrial oxidative phosphorylation.

CoQ10 has a number of important functions, both within mitochondria and elsewhere within cells. Within mitochondria, CoQ10 has a key role in the generation of ATP via oxidative phosphorylation, as an electron carrier from complex I and II to complex III in the mitochondrial electron transport chain.

Definition

ubiquinone: Any of a group of relatedquinone-derived compoundsthat serve as electron carriers in theelectron transport chain reactionsof cellular respiration. Coenzyme Qmolecules have side chains of differentlengths in different types of organismsbut function in similar ways.

Therapeutic Function

UBIDECARENONE

InChI:InChI=1/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+

303-98-0 Relevant articles

Coenzyme Q10 also seems to have antioxidant activity.

David Mantle ,Guillermo Lopez-Lluch, Iain Parry Hargreaves

,International Journal of Molecular Sciences (IJMS)(2023, 24(3), 2585)

The variable success in the outcome of randomised controlled trials supplementing coenzyme Q10 (CoQ10) may in turn be associated with a number of currently unresolved issues relating to CoQ10 metabolism. In this article, we have reviewed what is currently known about these factors and where gaps in knowledge exist that need to be further elucidated.

Coenzyme Q10 and Dementia: A Systematic Review

Félix Javier Jiménez-Jiménez ,Hortensia Alonso-Navarro ,Elena García-Martín ,José A. G. Agúndez

Antioxidants 2023, 12(2), 533

We also revised the possible therapeutic effects of CoQ10 in experimental models of AD and other dementias (which showed important neuroprotective effects of coenzyme Q10) and in humans with AD, other dementias, and mild cognitive impairment (with inconclusive results). The potential role of CoQ10 treatment in AD and in improving memory in aged rodents shown in experimental models deserves future studies in patients with AD, other causes of dementia, and mild cognitive impairment.

303-98-0 Process route

: 75-24-1
trimethylaluminum

: 202843-56-9
2-chloromethyl-5,6-dimethoxy-3-methyl-[1,4]benzoquinone

: 400010-22-2
(all-E)-2,6,10,14,18,22,26,30,34-nonamethyl-2,6,10,14,18,22,26,30,34-nonacontanonaen-38-yne

: 303-98-0,55127-92-9
ubidecarenone

Conditions

Conditions	Yield
trimethylaluminum; (all-E)-2,6,10,14,18,22,26,30,34-nonamethyl-2,6,10,14,18,22,26,30,34-nonacontanonaen-38-yne; With zirconocene dichloride; In 1,2-dichloro-ethane; at 23 ℃; for 1h; 2-chloromethyl-5,6-dimethoxy-3-methyl-[1,4]benzoquinone; With n-butyllithium; Cl₂Ni(PPh)2; triphenylphosphine; In tetrahydrofuran; at 23 ℃; for 1h; Further stages.;	90%
trimethylaluminum; (all-E)-2,6,10,14,18,22,26,30,34-nonamethyl-2,6,10,14,18,22,26,30,34-nonacontanonaen-38-yne; zirconocene dichloride; In dichloromethane; chlorobenzene; at -15 - 0 ℃; 2-chloromethyl-5,6-dimethoxy-3-methyl-[1,4]benzoquinone; With bis(triphenylphosphine)nickel(II) chloride; n-butyllithium; In tetrahydrofuran; at -20 ℃; for 2h; Further stages.;	89%
trimethylaluminum; (all-E)-2,6,10,14,18,22,26,30,34-nonamethyl-2,6,10,14,18,22,26,30,34-nonacontanonaen-38-yne; With methylalumoxane; rac-ethylenebis(1-indenyl)zirconium(IV) chloride; In toluene; at 20 ℃; for 22h; 2-chloromethyl-5,6-dimethoxy-3-methyl-[1,4]benzoquinone; bis(triphenylphosphine)nickel(II) chloride; n-butyllithium; In tetrahydrofuran; at -20 ℃; for 2h;	88%

: 899809-10-0
2-hydroxy-3,4,5-trimethoxy-6-((2E)-decaprenyl)-toluene

: 303-98-0,55127-92-9
ubidecarenone

Conditions

Conditions	Yield
With iron(III) chloride; In dichloromethane; acetonitrile; at 0 - 5 ℃; for 0.5h; Product distribution / selectivity;	100%
With iron(III) chloride; In dichloromethane; water; acetonitrile; at 0 - 5 ℃; for 0.5h; Product distribution / selectivity;	100%
With iron(III) chloride; In di-isopropyl ether; water; ethyl acetate; at 0 - 5 ℃; for 0.5h; Product distribution / selectivity;	95%
With ammonium cerium(IV) nitrate; In dichloromethane; water; acetonitrile; Product distribution / selectivity;	61%
2-hydroxy-3,4,5-trimethoxy-6-((2E)-decaprenyl)-toluene; With iron(III) chloride; In water; isopropyl alcohol; at 40 - 45 ℃; for 6h; With water; In isopropyl alcohol; Product distribution / selectivity;
With oxygen; iron(III) chloride; In tetrahydrofuran; ethanol; for 0.5h;	408 mg
With iron(III) chloride; In water; isopropyl alcohol; for 3h; Product distribution / selectivity;

303-98-0 Upstream products

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decaprenol
3066-90-8
2,3-dimethoxy-5-methylbenzene-1,4-diol
59640-02-7
3,7,11,15,19,23,27,31,35,39-decamethyl-1,6,10,14,18,22,26,30,34,38-tetracontadecaene-3-ol
75426-26-5
ubiquinol