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53-43-0

Product Name：Dehydroepiandrosterone
Molecular Formula：C₁₉H₂₈O₂
Purity：99%
Molecular Weight：

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Product Details

Appearance:white fine crystalline powder

Best price 53-43-0, factory sells Dehydroepiandrosterone with low price

Molecular Formula:C19H28O2
Molecular Weight:288.43
Appearance/Colour:white fine crystalline powder
Vapor Pressure:4.54E-09mmHg at 25°C
Melting Point:149-151 °C(lit.)
Refractive Index:1.56
Boiling Point:426.7 °C at 760 mmHg
PKA:15.02±0.60(Predicted)
Flash Point:182.1 °C
PSA：37.30000
Density:1.12 g/cm³
LogP:3.87920

Dehydroepiandrosterone 53-43-0 Usage

Dehydroepiandrosterone (DHEA) is a steroid hormone that is a popular nonprescription oral “dietary supplement” used by men to enhance cognitive function, mood, libido, and athletic performance. Dehydroepiandrosterone (DHEA) is an androgen produced by the zona reticularis of the adrenal gland. The biological significance of dehydroepiandrosterone (DHEA) which, in the form of its sulfated ester is the most abundant steroid hormone in human plasma, is an enigma.

InChI:InChI=1/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-16,20H,4-11H2,1-2H3/t13-,14-,15?,16?,18-,19-/m0/s1

53-43-0 Relevant articles

Functions of dehydroepiandrosterone in relation to breast cancer

Robert T. Chatterton

Steroids Volume 179, March 2022, 108970

Dehydroepiandrosterone sulfate (DS) and DHEA have an association with increasing lifespan, yet there is a declining benefit as people age.

A steroidogenic pathway for sulfonated steroids: The metabolism of pregnenolone sulfate

Neunzig,Sánchez-Guijo,Mosa,Hartmann,Geyer,Wudy,Bernhardt

, p. 324 - 333 (2014)

In many tissues sulfonated steroids exceed the concentration of free steroids and recently they were also shown to fulfill important physiological functions. We could confirm that PregS is metabolized to 17OH-PregS, strengthening the potential physiological meaning of a pathway for sulfonated steroids.

Dehydroepiandrosterone sulfate (DS) and DHEA have an association with increasing lifespan, yet there is a declining benefit as people age.

Asmaa A. Mahmoud, Asmaa M. Elfiky, Faten S. Abo-Zeid

Steroids Volume 177, January 2022, 108936

Dehydroepiandrosterone (DHEA) administration to prepubertal rats stimulates androgen biosynthesis and generation of the PCOS model. The present study aimed to evaluate the anti-androgenic effects of quercetin (Q) in comparison with metformin (MET) on hyperandrogenism and ovarian dysfunction in a DHEA-induced PCOS rat model.

53-43-0 Process route

: 53-43-0
dehydroepiandrosterone

: 100-52-7
benzaldehyde

Conditions

Conditions	Yield

: 63-05-8
Androstenedione

: 53-43-0
dehydroepiandrosterone

Conditions

Conditions	Yield
Androstenedione; With titanium(IV) oxide; platinum; In toluene; at 100 ℃; for 3h; With hydrogen; In toluene; for 8h; under 15001.5 Torr; Temperature; Reagent/catalyst; Pressure;	85%
Multi-step reaction with 2 steps 1.1: potassium tert-butylate / tert-butyl alcohol / 1.5 h / 35 - 40 °C / Inert atmosphere 1.2: 20 - 25 °C 2.1: NADP; magnesium(II) chloride hexahydrate; alpha-D-glucopyranose; NAD+ / 2-methyltetrahydrofuran; aq. phosphate buffer / 20 - 32 °C / Enzymatic reaction With alpha-D-glucopyranose; magnesium(II) chloride hexahydrate; potassium tert-butylate; NADP; NAD+; In 2-methyltetrahydrofuran; aq. phosphate buffer; tert-butyl alcohol;
Multi-step reaction with 2 steps 1: potassium tert-butylate / tert-butyl alcohol / 1 h / 30 - 35 °C / Inert atmosphere 2: D-glucose; NAD; glucose dehydrogenase (CDX-901)_; ketoreductase from Sphingomonas wittichii; potassium carbonate / ethyl acetate; aq. phosphate buffer / 21 h / 32.5 °C / pH 6.3 - 6.5 / Inert atmosphere; Enzymatic reaction With D-glucose; glucose dehydrogenase (CDX-901)_; ketoreductase from Sphingomonas wittichii; potassium tert-butylate; NAD; potassium carbonate; In aq. phosphate buffer; ethyl acetate; tert-butyl alcohol;
Multi-step reaction with 4 steps 1: aluminum (III) chloride; 5-sulfosalicylic Acid / 5 h / 20 - 30 °C / Inert atmosphere; Large scale 2: orthoformic acid triethyl ester; boron trifluoride diethyl etherate / dichloromethane / 5 h / 20 - 30 °C / Inert atmosphere 3: calcium borohydride / dichloromethane / 15 h / -20 - -15 °C 4: toluene-4-sulfonic acid / acetone; water / 1 h / 45 - 50 °C / Inert atmosphere With aluminum (III) chloride; calcium borohydride; boron trifluoride diethyl etherate; toluene-4-sulfonic acid; orthoformic acid triethyl ester; 5-sulfosalicylic Acid; In dichloromethane; water; acetone;