Product Details
Appearance:white crystalline odourless solid
Testosterone 58-22-0 factory sells, in stock, Good Supplier In China
- Molecular Formula:C19H28O2
- Molecular Weight:288.43
- Appearance/Colour:white crystalline odourless solid
- Vapor Pressure:2.6E-09mmHg at 25°C
- Melting Point:152-156 °C
- Refractive Index:1.56
- Boiling Point:432.9 °C at 760 mmHg
- PKA:15.06±0.60(Predicted)
- Flash Point:184.7 °C
- PSA：37.30000
- Density:1.12 g/cm3
- LogP:3.87920
Testosterone 58-22-0 Usage
Testosterone is the most important hormone in male health, which is a steroid hormone with 19 carbon atoms. Low testosterone levels in men are associated with sexual dysfunction (low sexual desire, erectile dysfunction), reduced skeletal muscle mass and strength, decreased bone mineral density, increased cardiovascular risk and alterations of the glycometabolic profile. Studies have shown that the serum total testosterone (TT) levels are decreased due to aging and in the presence of comorbidities such as obesity, diabetes mellitus, and cardiovascular diseases, which are quite common in SARS-CoV-2 patients.
Definition
ChEBI: An androstanoid having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-41C-5..
Hazard
A confirmed carcinogen.
Biological Activity
Endogenous androgen receptor agonist.
InChI:InChI=1/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14?,15?,16?,17-,18-,19-/m0/s1
Testosterone 58-22-0 Relevant articles
The Role of Testosterone in the Elderly: What Do We Know?
Biagio Barone ,Luigi Napolitano ,Marco Abate ,Luigi Cirillo ,Pasquale Reccia ,Francesco Passaro ,Carmine Turco ,Simone Morra ,Francesco Mastrangelo ,Antonio Scarpato ,Ugo Amicuzi ,Vincenzo Morgera ,Lorenzo Romano ,Francesco Paolo Calace ,Savio Domenico Pandolfo ,Luigi De Luca ,Achille Aveta ,Enrico Sicignano ,Massimiliano Trivellato ,Gianluca Spena ,Carlo D’Alterio ,Giovanni Maria Fusco ,Raffaele Vitale ,Davide Arcaniolo and Felice Crocetto
Int. J. Mol. Sci. 2022, 23(7), 3535;
As result, the use of testosterone replacement therapy (TRT) in clinical practice has been an appealing perspective. However, the issue related to the potential adverse effects of TRT, and in particular its impact on cardiovascular events and mortality, have represented a controversial topic of discussion.
The relationship of serum testosterone levels with the clinical course and prognosis of COVID-19 disease in male patients: A prospective study
Ahmet Emre Cinislioglu, Nazan Cinislioglu, Saban Oguz Demirdogen, Emre Sam, Fatih Akkas, Mehmet Sefa Altay, Mustafa Utlu, Irem Akin Sen, Fatih Yildirim, Seyfi Kartal, Hasan Riza Aydin, Ibrahim Karabulut, Isa Ozbey
Andrology, Volume10, Issue1 January 2022 Pages 24-33
The measured serum total testosterone level of the COVID-19 patients group was found to be significantly lower than that of the control group (median, 140 ng/dl; range, 0.21–328, 322 ng/dl; range, median, 125–674, p < 0.001, respectively).
58-22-0 Process route
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- 521-17-5,1963-03-7,4593-57-1,4593-58-2,14504-94-0,16895-59-3,47122-33-8,64162-67-0,75767-22-5,139973-51-6,151284-19-4
5-androstenediol
-
- 58-22-0
testosterone
-
- 2487-48-1,7522-54-5,62357-03-3,53-00-9
3β,7α-dihydroxyandrost-5-ene-17-one
-
- 2697-85-0,62357-04-4,2226-66-6
Androst-5-ene-3beta,7alpha,17beta-triol
-
- 2697-85-0
5-androstene-3β,7β,17β-triol
| Conditions | Yield |
|---|---|
|
With water; In ethanol; for 120h; Microbiological reaction;
|
-
- 53-43-0
dehydroepiandrosterone
-
- 58-22-0
testosterone
-
- 2487-48-1,7522-54-5,62357-03-3,53-00-9
3β,7α-dihydroxyandrost-5-ene-17-one
-
- 2697-85-0,62357-04-4,2226-66-6
Androst-5-ene-3beta,7alpha,17beta-triol
-
- 2697-85-0
5-androstene-3β,7β,17β-triol
| Conditions | Yield |
|---|---|
|
Multi-step reaction with 2 steps
1: sodium tetrahydroborate / methanol
2: water / ethanol / 120 h / Microbiological reaction
With sodium tetrahydroborate; water; In methanol; ethanol;
|
58-22-0 Upstream products
-
110-86-1
pyridine
-
5062-49-7
4β-bromo-17β-hydroxy-5β-androstan-3-one
-
67-56-1
methanol
-
132059-74-6
3β.17β.3'β.17'β-tetrahydroxy-[3.3']bi[androsten-(4)-yl]
58-22-0 Downstream products
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1169-49-9
Testosterone 2-methyl propanoate
-
521-15-3
3-(3-oxo-4-androsten-17β-oxycarbonyl)propionic acid
-
3410-54-6
3-oxoandrost-4-en-17β-yl butyrate
-
3129-42-8
3-oxo-androst-4-en-17β-yl-methyl formate
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