Product Details
Metformin 657-24-9 trader, low price, fast Delivery
- Molecular Formula:C4H11N5
- Molecular Weight:129.165
- Melting Point:199-200 °C
- Refractive Index:1.5760 (estimate)
- Boiling Point:224.1 °C at 760 mmHg
- PKA:pKa 2.8(H2O,t =32) (Uncertain)
- Flash Point:89.3 °C
- PSA：88.99000
- Density:1.28 g/cm3
- LogP:0.25650
Metformin Usage
Metformin is a biguanide compound which originated from the extraction of goat’s rue plants. Metformin (Glucophage) was used in Europe for many years before it was approved for use in the United States in 1995. Metformin is the only approved biguanide for the treatment of patients with NIDDM that are refractory to dietary management alone. Metformin is quickly absorbed from the small intestine. Metformin remains the first-line pharmacological choice for the management of hyperglycaemia in T2DM. It works to decrease blood glucose during pregnancy.
InChI:InChI=1/C4H11N5/c1-9(2)4(7)8-3(5)6/h1-2H3,(H5,5,6,7,8)
657-24-9 Relevant articles
Is it still worth pursuing the repurposing of metformin as a cancer therapeutic?
SR Lord, AL Harris
British Journal of Cancer volume 128, pages958–966 (2023)
This perspective article summarises how interest initially developed in the oncological potential of metformin and the diverse clinical programme of work to date including our contribution to establishing the intra-tumoral pharmacodynamic effects of metformin in the clinic. We also discuss the lessons that can be learnt from this experience and whether a further clinical investigation of metformin in cancer is warranted.
Mechanisms of cancer cell killing by metformin: A review on different cell death pathways
Xiao-yu Wu, Wen-Wen Xu, Xiang-kun Huan, Guan-nan Wu, Gang Li, Yu-Hong Zhou & Masoud Najafi
Molecular and Cellular Biochemistry volume 478, pages197–214 (2023)
We discuss the modulatory roles of metformin on different cancer cell death pathways including apoptosis, mitotic catastrophe, senescence, autophagy, ferroptosis and pyroptosis.
657-24-9 Process route
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N,N-dimethylimidodicarbonimidic diamide hydrochloride
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- 657-24-9
dimethylbiguanide
| Conditions | Yield |
|---|---|
|
With sodium hydroxide; In isopropyl alcohol; at 0 - 40 ℃; for 18.2h; Temperature; Solvent;
|
93% |
|
With sodium hydroxide; In isopropyl alcohol; at 39.84 ℃; for 3h;
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|
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With sodium; In ethanol; at 60 ℃; for 1h; Reagent/catalyst; Solvent; Temperature;
|
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- 1115-70-4
metformin hydrochloride
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- 657-24-9
dimethylbiguanide
| Conditions | Yield |
|---|---|
|
With sodium hydroxide; In water; at 20 ℃; for 0.5h;
|
100% |
|
With sodium hydroxide; In water; at 20 ℃; for 0.5h;
|
99% |
|
With sodium hydroxide; In ethanol; for 5h;
|
99% |
|
With sodium hydroxide; In water; at 20 ℃; for 0.5h; Reagent/catalyst; Temperature; Solvent;
|
99% |
|
With sodium hydroxide; In ethanol; at 20 ℃; for 1h;
|
99% |
|
With potassium hydroxide; In isopropyl alcohol; at 50 ℃; for 2h;
|
98.5% |
|
With potassium hydroxide; In isopropyl alcohol; at 50 ℃; for 2h;
|
98% |
|
With sodium hydroxide; In water; at 20 ℃; for 0.5h;
|
95% |
|
With sodium hydroxide; In ethanol; at 70 ℃; Product distribution / selectivity;
|
83.4% |
|
With sodium hydroxide; In ethanol; dichloromethane; at 70 ℃; Product distribution / selectivity;
|
83.4% |
|
With sodium hydroxide; In water; for 2h;
|
73.2% |
|
With sodium hydroxide; In methanol; at 20 ℃; Product distribution / selectivity;
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59.84% |
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With potassium hydroxide; In isopropyl alcohol; at 50 - 60 ℃;
|
50% |
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With sodium hydroxide; In isopropyl alcohol; at 39.85 ℃; for 1h;
|
|
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With Amberlyst A-26 (OH); In methanol; water;
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|
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With Amberlyst A26 (OH); In methanol; water; Product distribution / selectivity;
|
|
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With Amberlyst A26 (OH); In water; pH=~ 7 - 8; Product distribution / selectivity;
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|
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With sodium methylate; In methanol; for 0.166667h; Product distribution / selectivity;
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With sodium hydroxide; In methanol; water; for 0.333333h; Product distribution / selectivity;
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|
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With potassium hydroxide; In methanol; ethanol; at 10 - 40 ℃; Inert atmosphere;
|
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With potassium hydroxide; for 2h; Product distribution / selectivity;
|
|
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With sodium hydroxide; In ethanol; at 20 ℃; for 1h;
|
|
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With sodium hydroxide; In water; at 20 ℃; for 0.5h;
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3.18 g |
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With sodium hydroxide;
|
|
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With barium(II) hydroxide; at 20 ℃; for 4h; Reagent/catalyst; Temperature;
|
|
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With sodium hydroxide; at 20 ℃; for 0.5h;
|
1.8 g |
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With sodium hydroxide; In methanol; at 20 ℃; for 2h;
|
|
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With sodium hydroxide; In water; acetone; at 20 ℃; for 2.66667h; Product distribution / selectivity;
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With sodium hydroxide; In ethanol; at 20 ℃; for 2h; Product distribution / selectivity;
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657-24-9 Upstream products
-
506-59-2
N,N-dimethylammonium chloride
-
127099-85-8
N-Cyanoguanidine
-
124-40-3
dimethyl amine
-
1115-70-4
metformin hydrochloride
657-24-9 Downstream products
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4039-98-9
N2,N2-dimethyl-1,3,5-triazine-2,4-diamine
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104509-76-4
N,N-dimethyl-N'-sulfanilyl-guanidine
-
1674-64-2
N-(4-methylphenylsulfonyl)metformin
-
1609-00-3
1-methylbiguanide
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