Product Details
Appearance:white crystalline powder
Factory sells Artesunate 88495-63-0 low price, Good Supplier In China
- Molecular Formula:C19H28O8
- Molecular Weight:384.427
- Appearance/Colour:white crystalline powder
- Melting Point:132-135 °C
- Refractive Index:1.543
- Boiling Point:502.1 °C at 760 mmHg
- PKA:4.28±0.17(Predicted)
- Flash Point:173.5 °C
- PSA：100.52000
- Density:1.31 g/cm3
- LogP:2.60240
88495-63-0 Usage
Artesunate (ART), also known as dihydroartemisinin-12-α-succinate, is a semisynthetic peroxide-bridged sesquiterpene lactone compound derived from artemisinin, the bioactive component of the Chinese medicinal herb called Artemisia annua. Artesunate is the drug of choice for treating patients with severe malaria. Artesunate has subsequently been the treatment of choice for complicated malaria over the past decade, especially in North America, Europe, and Southeast Asia. Apart from treating malaria, artesunate has also been found to have biological activity against a variety of cancers and viruses.
Brand name
Arsumax (Knoll, Switzerland).
InChI:InChI=1/C19H28O8/c1-10-4-5-13-11(2)15(16(22)23-9-7-14(20)21)24-17-19(13)12(10)6-8-18(3,25-17)26-27-19/h10-13,15,17H,4-9H2,1-3H3,(H,20,21)/t10-,11-,12+,13+,15-,17-,18-,19?/m1/s1
88495-63-0 Relevant articles
Anti-malaria drug artesunate prevents development of amyloid-β pathology in mice by upregulating PICALM at the blood-brain barrier
Kassandra Kisler, Abhay P. Sagare, Divna Lazic, Sam Bazzi, Erica Lawson, Ching-Ju Hsu, Yaoming Wang, Anita Ramanathan, Amy R. Nelson, Zhen Zhao & Berislav V. Zlokovic
Molecular Neurodegeneration volume 18, Article number: 7 (2023)
Our screen identified anti-malaria drug artesunate as the lead hit. Artesunate increases PICALM levels and Aβ clearance at the BBB which prevents development of Aβ pathology and functional deficits in mice and holds potential for translation to human AD.
Food and Drug Administration Approval of Artesunate for Severe Malaria: Enough to Achieve Best Practice?
Christine M Thomas, William M Stauffer, Jonathan D Alpern
Clinical Infectious Diseases, Volume 76, Issue 3, 1 February 2023, Pages e864–e866
As US health systems weigh the decision to stock artesunate, we propose a hospital tier framework to inform this decision and support clinicians caring for patients who present with severe malaria.
Pre-referral rectal artesunate is no “magic bullet” in weak health systems
Manuel W. Hetzel, Jean Okitawutshu, Antoinette Tshefu, Elizabeth Omoluabi, Phyllis Awor, Aita Signorell, Marek Kwiatkowski, Mark J. Lambiris, Theodoor Visser, Justin M. Cohen, Valentina Buj, Christian Burri & Christian Lengeler
BMC Medicine volume 21, Article number: 119 (2023)
Presenting RAS as a “magic bullet” in these settings distracts from the most urgent priority: fixing local health systems so they can provide a functioning continuum of care for sick children, from the community to a referral facility.
88495-63-0 Process route
-
- 108-30-5
succinic acid anhydride
-
- 63968-64-9
C12H13O2(CH3)3(O)(OO)
-
- 88495-63-0
artesunate
| Conditions | Yield |
|---|---|
|
C12H13O2(CH3)3(O)(OO); With sodium tetrahydroborate; cation exchange resin; In tetrahydrofuran; at 20 - 35 ℃; for 0.666667h;
succinic acid anhydride; With triethylamine; In tetrahydrofuran; at 20 - 35 ℃; for 1h;
|
96% |
|
C12H13O2(CH3)3(O)(OO); With sodium tetrahydroborate; D-glucose; In 1,4-dioxane; at 20 - 30 ℃; for 2h;
succinic acid anhydride; In 1,4-dioxane; at 20 - 30 ℃; for 2h;
|
93% |
|
C12H13O2(CH3)3(O)(OO); With sodium tetrahydroborate; cation exchange resin; In tetrahydrofuran; at 20 - 35 ℃; for 0.75h;
succinic acid anhydride; With sodium hydrogencarbonate; In tetrahydrofuran; at 20 - 35 ℃; for 1.25h;
|
93% |
|
C12H13O2(CH3)3(O)(OO); With sodium tetrahydroborate; D-glucose; In 1,4-dioxane; at 20 - 30 ℃; for 2h;
succinic acid anhydride; With triethylamine; In 1,4-dioxane; at 20 - 30 ℃; for 2h;
|
91.2% |
|
C12H13O2(CH3)3(O)(OO); With sodium tetrahydroborate; D-glucose; In 1,4-dioxane; at 20 - 30 ℃; for 2h;
succinic acid anhydride; With sodium hydrogencarbonate; In 1,4-dioxane; at 20 - 30 ℃; for 2h;
|
89.6% |
|
C12H13O2(CH3)3(O)(OO); With sodium tetrahydroborate; D-glucose; In tetrahydrofuran; at 20 - 30 ℃; for 2h;
succinic acid anhydride; With triethylamine; In tetrahydrofuran; at 20 - 30 ℃; for 2h;
|
87.4% |
|
C12H13O2(CH3)3(O)(OO); With sodium tetrahydroborate; cation exchange resin; In 1,4-dioxane; at 20 - 35 ℃; for 0.75 - 0.916667h;
succinic acid anhydride; With triethylamine; In 1,4-dioxane; at 20 - 35 ℃; for 1.25h;
|
85% |
-
- 108-30-5
succinic acid anhydride
-
- 81496-81-3
dihydroartesiminin
-
- 88495-63-0
artesunate
| Conditions | Yield |
|---|---|
|
With dmap; In 1,2-dichloro-ethane; at 45 ℃; for 6h; Reagent/catalyst; Solvent; Temperature; Industrial scale;
|
97% |
88495-63-0 Upstream products
-
108-30-5
succinic acid anhydride
-
81496-81-3
dihydroartesiminin
-
71939-50-9
dihydroartemisinin
-
71939-50-9
dihydroartemisinin
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