282526-98-1

  • Product Name:Cetilistat
  • Molecular Formula:C25H39NO3
  • Purity:99%
  • Molecular Weight:
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Product Details

Appearance:Off-white cryst.

Cetilistat 282526-98-1 trader with best price, for sale

  • Molecular Formula:C25H39NO3
  • Molecular Weight:401.59
  • Appearance/Colour:Off-white cryst. 
  • Vapor Pressure:0mmHg at 25°C 
  • Melting Point:72.0 to 76.0 °C 
  • Refractive Index:1.521 
  • Boiling Point:509.671 °C at 760 mmHg 
  • PKA:2.96±0.20(Predicted) 
  • Flash Point:158.925 °C 
  • PSA:52.33000 
  • Density:1.027 g/cm3 
  • LogP:7.35650 

282526-98-1 Usage

Cetilistat is a potent inhibitor of human and rat pancreatic lipase with IC50s of 15 and 136 nM, respectively, with little inhibition of trypsin or chymotrypsin. Cetilistat is used to aid weight loss in obese individuals. It should be used along with regular physical activity and a healthy diet. It works in the small intestine and stomach and prevents the action of enzymes that breakdown fat which is absorbed by the body. There are no any side effects of Cetilistat for the heart. Safe. Severe Interaction of Cetilistat with Other Drugs.

 

InChI:InChI=1/C25H39NO3/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-19-28-25-26-23-18-17-21(2)20-22(23)24(27)29-25/h17-18,20H,3-16,19H2,1-2H3

282526-98-1 Relevant articles

Process for efficiently synthesizing Cetilistat by taking 2-amino-5-methyl benzoic acid as raw material

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Paragraph 0053; 0058-0059; 0064; 0068-0070, (2020/04/02)

The invention discloses a process for efficiently synthesizing Cetilistat by taking 2-amino-5-methyl benzoic acid as a raw material. According tothe method, the reaction steps for synthesizing the Cetilistat are few, the process route is short, side reactions are few, the yield of the final product is high, and the purity is more than 99%.

NOVEL PROCESSES FOR THE PREPARATION OF 2-OXY-BENZOXAZINONE DERIVATIVES

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Page/Page column 17; 18, (2018/02/28)

Provided herein are novel, commercially viable and industrially advantageous processes for the preparation of 2-hexadecyloxy-6-methyl-4H-3,1-benzoxazin-4-one, and its intermediates, in high yield and purity.

Cetilistat solid dispersion and medicinal preparation prepared from the solid dispersion

Guihong Ma, Yanyao Chen, Limin Liu, Yuxian Geng, Yunxia Chan

Google Patents (Jul 27, 2016)

The invention relates to cetilistat solid dispersion, and a medicinal preparation prepared from the solid dispersion.

Method of preparing Cetilistat through one-pot method

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Paragraph 0027-0032; 0033-0038; 0039-0042; 0043-0046, (2017/08/27)

According to the method, with selection of a mixed solution system as a reaction medium and the methane sulfonyl chloride as a lactonization reagent and adoption of the one-pot method to prepare the Cetilistat, an obtained product is high in yield and purity; the process is simple and not tedious, separation and purification of an intermediate are not needed, postprocessing is liable to operate, requirement on equipment is not high, the industrial production is facilitated.

282526-98-1 Process route

2-(((hexadecyloxy)carbonyl)amino)5-methylbenzoic acid
890655-08-0

2-(((hexadecyloxy)carbonyl)amino)5-methylbenzoic acid

2-hexadecyloxy-6-methyl-4-chloro-1-benzoxazin-4-one
282526-98-1,335149-24-1

2-hexadecyloxy-6-methyl-4-chloro-1-benzoxazin-4-one

Conditions
Conditions Yield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; Solvent; Reagent/catalyst;
96.5%
With 1,1'-carbonyldiimidazole; In dichloromethane; Reagent/catalyst;
92%
With pyridine; chloroformic acid ethyl ester; at 0 - 10 ℃; for 1h; Reagent/catalyst; Concentration;
85.5%
With pyridine; chloroformic acid ethyl ester; at 20 ℃; for 3h; Cooling with ice;
85%
2-(((hexadecyloxy)carbonyl)amino)5-methylbenzoic acid; With pyridine; In dichloromethane; at 25 - 30 ℃; for 0.166667h;
With chloroformic acid ethyl ester; In dichloromethane; at 0 - 35 ℃; for 4h; Reagent/catalyst;
83.3%
With pyridine; chloroformic acid ethyl ester; at 0 - 20 ℃; for 3.33333h;
82%
With methanesulfonyl chloride; In tetrahydrofuran; at 10 - 25 ℃; for 1.5h;
 
hexadecanyl p-trifluoromethylsulfonate

hexadecanyl p-trifluoromethylsulfonate

2-hexadecyloxy-6-methyl-4-chloro-1-benzoxazin-4-one
282526-98-1,335149-24-1

2-hexadecyloxy-6-methyl-4-chloro-1-benzoxazin-4-one

Conditions
Conditions Yield
With triethylamine; In dichloromethane; Cooling with ice; Reflux;
90%

282526-98-1 Upstream products

  • 890655-08-0
    890655-08-0

    2-(((hexadecyloxy)carbonyl)amino)5-methylbenzoic acid

  • 541-41-3
    541-41-3

    chloroformic acid ethyl ester

  • 36653-82-4
    36653-82-4

    1-Hexadecanol

  • 26272-90-2
    26272-90-2

    cetyl chloroformate

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