113-92-8
- Product Name：Chlorpheniramine maleate
- Molecular Formula：C20H23ClN2O4
- Purity：99%
- Molecular Weight：
Product Details
Appearance:White crystalline powder
Best quality Chlorpheniramine maleate 113-92-8 supplier with factory price
- Molecular Formula:C20H23ClN2O4
- Molecular Weight:390.867
- Appearance/Colour:White crystalline powder
- Vapor Pressure:2.9E-14mmHg at 25°C
- Melting Point:130-135 ºC
- Refractive Index:1.6800 (estimate)
- Boiling Point:379 ºC at 760 mmHg
- Flash Point:183 ºC
- PSA：90.73000
- Density:1.107 g/cm3
- LogP:3.53040
Chlorpheniramine maleate 113-92-8 Usage
Chlorpheniramine maleate (CPM) is a histamine H1 receptor antagonist with an IC75 value of 0.0016 μg/ml for reversal of histamine-induced spasms in isolated guinea pig ileum. It has been used to relieve symptoms of allergy, hay fever, and the common cold. Chlorpheniramine maleate is a racemic mixture of optical isomers. It is an odorless, white crystalline solid. Analysis of chlorpheniramine maleate has been determined for carbon, hydrogen, nitrogen, and chlorine.
Chlorphenamine maleate (CP) is an antihistamine used to treat the symptoms of allergic situations such as rhinitis (hay fever) [2]. CP is generally combined with other drugs such as acetaminophen, pseudoephedrine HCl, ascorbic acid, and caffeine to minimize the symptoms of cold and flu.
Brand name
Trimeton (Schering-Plough); Teldrin (GlaxoSmithKline).
Dosage forms
4 to 6 mg PO q4–6h. Maximum daily dose is 24 mg for adults and children 12 years or older. Found frequently in combination with acetaminophen and pseudoephedrine.
InChI:InChI=1/C16H19ClN2.C4H4O4/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-9,11,15H,10,12H2,1-2H3;1-2H,(H,5,6)(H,7,8)
113-92-8 Relevant articles
Chlorpheniramine Maleate Throat Spray for the Treatment of COVID-19-Induced Acute Viral Pharyngitis: Case Series
Mari L. Tesch , Rahul Dasgupta , Uzzam Ahmed Khawaja , Marcos Sanchez-Gonzalez , Rahaghi Franck
Paragraph 0023-0031, (2021/12/07)
Available for many years, Chlorpheniramine Maleate (CPM), is considered a low-cost and safe first-generation antihistamine displaying antiallergic, anti-inflammatory, and as of recently, identified as a broad-spectrum antiviral agent with activity against influenzas A/B viruses and SARS-CoV-2.
The Effect of Chlorpheniramine Maleate on the bioluminescence of Vibrio fischeri
H Gill
Spring Valley High School
The invention provides chlorpheniramine maleate as well as a preparation method and application thereof. The chlorpheniramine maleate obtained by the preparation method disclosed by the invention has the advantages of higher purity, no solvent residue and mild reaction conditions, and is easy for industrial production.
Understanding the Molecular Interactions of Chlorpheniramine Maleate with Imidazolium Based Ionic Liquids in Aqueous System at Different Temperature T = (288.15 K to 318.15 K): Physicochemical, Thermodynamics and Transport Studies
Meena Sharma, Jeetinder Singh, Shubham Sharma, Shubham Sharma
Thermodynamics and Transport
In order to adjudicate and understand the synergy between the drug chlorpheniramine maleate (CPM) and ionic liquids (ILs) such as 1‑butyl-3-methylimidazolium chloride [BMIm]Cl, 1-hexyl-3-methylimidazolium chloride [HMIm]Cl and 1-octyl-3-methylimidazolium chloride [OMIm]Cl in aqueous medium volumetric, acoustic and viscometric properties of binary and ternary systems are studied.
113-92-8 Process route
-
- 110-16-7,26099-09-2
maleic acid
-
- 132-22-9
Chlorpheniramine
-
- 113-92-8
chlorphenamine maleate
| Conditions | Yield |
|---|---|
|
In ethanol; n-heptane; at 55 ℃;
|
98% |
|
In ethanol; at -2 - 0 ℃; for 2.5h;
|
350 g |
|
With pyrographite; In ethanol; at 80 ℃; for 1.5h; Temperature; Large scale;
|
|
|
With pyrographite; In ethanol; at 80 ℃; for 2h; Temperature;
|
-
- 64-18-6
formic acid
-
- 20619-13-0
Didesmethylchlorpheniramine
-
- 110-16-7,26099-09-2
maleic acid
-
- 113-92-8
chlorphenamine maleate
| Conditions | Yield |
|---|---|
|
formic acid; Didesmethylchlorpheniramine; In water; N,N-dimethyl-formamide; at 100 ℃; for 24h;
maleic acid; In isopropyl alcohol; at 80 ℃; for 2h;
|
88.8% |
113-92-8 Upstream products
-
140-53-4
p-chlorobenzyl cyanide
-
110-16-7
maleic acid
-
132-22-9
Chlorpheniramine
-
4350-41-8
2-(4-chlorobenzyl)pyridine
113-92-8 Downstream products
-
2438-32-6
dextrochlorpheniramine maleate
-
23095-76-3
(-)-Chlorpheniramine maleate
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