119302-91-9

Rocuronium bromide is a nondepolarizing neuromuscular blocking agent given before general anesthesia in preparation for surgery. Rocuronium injection is used with general anesthesia medicines for rapid sequence intubation and routine tracheal intubation. This medicine is also used to help relax the muscles during surgery or mechanical ventilation. This medicine is to be given only by your doctor or other trained health professional. With lower dosages of 0.3 - 0.45 mg rocuronium bromide per kg body weight (1 - 1 ½ x 2 x ED 90), the onset of the effect is slower and the duration of action is shorter (13 - 26 min). With high doses of 2 mg/kg, clinical duration is 110 minutes.

Definition

ChEBI: The organic bromide salt of a 5alpha androstane compound having 3alpha-hydroxy-, 17beta-acetoxy-, 2beta-morpholino- and 16beta-N-allyllyrrolidinium subs ituents.

Brand name

Zemuron (Organon).

Drug interactions

Potentially hazardous interactions with other drugs Anaesthetics: enhanced muscle relaxant effect. Anti-arrhythmics: procainamide enhances muscle relaxant effect. Rocuronium is metabolised by the liver to a less active metabolite, 17-desacetylrocuronium which is reported to have weak neuromuscular blocking effect. 

InChI:InChI=1/C32H53N2O4.BrH/c1-5-14-34(15-6-7-16-34)28-20-26-24-9-8-23-19-29(36)27(33-12-17-37-18-13-33)21-32(23,4)25(24)10-11-31(26,3)30(28)38-22(2)35;/h5,23-30,36H,1,6-21H2,2-4H3;1H/q+1;/p-1/t23?,24-,25?,26?,27+,28+,29?,30+,31+,32+;/m1./s1

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