Product Details
Appearance:off-white solid
Best quality top purity Pregabalin 148553-50-8 for sale
- Molecular Formula:C8H17NO2
- Molecular Weight:159.228
- Appearance/Colour:off-white solid
- Vapor Pressure:0.00153mmHg at 25°C
- Melting Point:194-196 °C
- Refractive Index:1.464
- Boiling Point:274 °C at 760 mmHg
- PKA:4.23±0.10(Predicted)
- Flash Point:119.5 °C
- PSA：63.32000
- Density:0.997 g/cm3
- LogP:1.78240
Top purity Pregabalin148553-50-8 Usage
Pregabalin (Lyrica) was the first drug approved by the Food and Drug Administration for the treatment of postherpetic neuralgia and diabetic neuropathy. Pregabalin has been used in the management of other anxiety disorders and acute anxiety states such as preoperative anxiety. It is widely used as a treatment for multiple neurological disorders. As a capping and reducing agent, the dose of pregabalin (PREG) must be customised according to patients’ characteristics and main symptoms.
Side Effects
Weight gain is one of the most common side effects with Lyrica (generic name: pregabalin) in both adults and children. Pregabalin treatment is associated with a high risk for bodyweight gain which in part depends on total anticonvulsant drug load.
InChI:InChI=1/C8H17NO2/c1-6(2)3-7(5-9)4-8(10)11/h6-7H,3-5,9H2,1-2H3,(H,10,11)/t7-/m0/s1
148553-50-8 Relevant articles
Efficacy and safety of pregabalin in eye pain: A systematic review
X Shen, X Chen, Y He, H Xu, J Zhu
Medicine, Volume 102, Number 6, 10 February 2023, pp. e32875-e32875(1)
The pregabalin is approved for the management of persistent pain. Pregabalin reduced acute eye pain but had no significant effect on long-term analgesia after ophthalmological surgery in adults. It had no effect on dry-eye symptoms after ocular surgery. Further studies on the safety of pregabalin in eye pain management
A meta-epidemiological study on the reported treatment effect of pregabalin in neuropathic pain trials over time
Emma T. L. Cheng ,Mohammad Cheik-Hussein,Noelle Lin,Adriane M. Lewin,James H. McAuley,Ian A. Harris
PloS one, January 20, 2023
We included randomized, placebo-controlled trials of pregabalin for treatment of neuropathic pain in adults. The reported treatment effect or analgesic efficacy of pregabalin from clinical trials has diminished over time. Clinical recommendations may need to be re-evaluated to account for recent evidence and to consider whether pregabalin therapy is indicated.
148553-50-8 Process route
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- 181289-21-4
5-methyl-3-(nitromethyl)hexanoic acid
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- 128013-69-4,130912-52-6,148553-50-8,148553-51-9
(R,S)-3-iso-butyl-4-aminobutyric acid
| Conditions | Yield |
|---|---|
|
With palladium 10% on activated carbon; hydrogen; In methanol; at 25 ℃; for 24h; under 760.051 Torr;
|
97% |
|
With hydrogen; 5%-palladium/activated carbon; In methanol; at 25 - 30 ℃; for 6 - 8h;
|
80% |
|
With hydrogen; 5%-palladium/activated carbon; In methanol; for 5 - 8h;
|
37% |
|
With hydrogen; 5% Pd(II)/C(eggshell); In methanol;
|
37% |
|
With hydrogen; nickel; In methanol; for 12h; under 2942.29 Torr;
|
|
|
With palladium 10% on activated carbon; hydrogen; In methanol; at 60 ℃; under 45004.5 Torr;
|
630 mg |
-
-
3-carbamoyl-5-methylhexanoic acid
-
- 128013-69-4,130912-52-6,148553-50-8,148553-51-9
(R,S)-3-iso-butyl-4-aminobutyric acid
| Conditions | Yield |
|---|---|
|
With lithium borohydride; In tetrahydrofuran; methanol; at 10 ℃; Reagent/catalyst;
|
88.4% |
|
With sodium hydroxide; In water; at 0 - 10 ℃;
|
79.8% |
148553-50-8 Upstream products
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216576-89-5
3-(1,3-Dioxo-1,3-dihydro-isoindol-2-ylmethyl)-5-methyl-hex-4-enoic acid ethyl ester
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216576-81-7
3-(1,3-Dioxo-1,3-dihydro-isoindol-2-ylmethyl)-pent-4-enoic acid ethyl ester
-
216576-90-8
4-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-formyl-butyric acid ethyl ester
-
34993-63-0
5-methyl-2-hexenoic acid ethyl ester
148553-50-8 Downstream products
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1026095-29-3
C8H8O3*C8H17NO2
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1078737-39-9
(S)-pregabalin-(-)-O,O'-dibenzoyl-L-tartrate
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185815-62-7
(S)-(+)-3-(aminomethyl)-5-methylhexanoic acid (S)-mandelate
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1136499-07-4
(S)-(+)-3-aminomethyl-5-methylhexanoic acid di-(O,O')-p-toluoyl-D-tartaric acid salt
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