63547-13-7
- Product Name：Acetamide,2-[(diphenylmethyl)sulfinyl]-N-hydroxy-
- Molecular Formula：C15H15NO3S
- Purity：99%
- Molecular Weight：
Product Details
Appearance:White, hygroscopic powder.
Adrafinil 63547-13-7 Phenylpiracetam for sale, Good Supplier In China
- Molecular Formula:C15H15NO3S
- Molecular Weight:289.355
- Appearance/Colour:White, hygroscopic powder.
- Melting Point:150-160 °C
- Refractive Index:1.652
- PKA:8.22±0.20(Predicted)
- PSA：85.61000
- Density:1.342 g/cm3
- LogP:3.28670
Adrafinil 63547-13-7 Usage
Analogues of adrafinil include modafinil, armodafinil, CRL-40,940, CRL-40,941, and fluorenol. It has effects similar to modafinil, which is a prescription drug that is used to treat narcolepsy. Adrafinil, 2-((diphenylmethyl)sulfinyl)-N-hydroxyacetamide, is a drug designed for the treatment of narcolepsy by promoting an awakened state, and to treat alertness and neurological symptoms in the elderly. Adrafinil is a research chemical that’s touted for its potential applications as a nootropic.
InChI:InChI=1/C15H15NO3S/c17-14(16-18)11-20(19)15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,15,18H,11H2,(H,16,17)
63547-13-7 Relevant articles
Oral administration of adrafinil improves discrimination learning in aged beagle dogs.
NW Milgram，CT Siwak，P Gruet，P Atkinson，H Callahan
, Pharmacology Biochemistry & Behavior June 2000
An effect of adrafinil on motivation may partially account for these findings; however, adrafinil did not significantly affect response latency. Adrafinil is believed to serve as an alpha-1 adrenoceptor agonist.
Synthesis and determination of the absolute configuration of the enantiomers of modafinil
Prisinzano, Thomas,Podobinski, John,Tidgewell, Kevin,Luo, Min,Swenson, Dale
, p. 1053 - 1058 (2007/10/03)
The asymmetric synthesis of both enantiomers of modafinil, a unique CNS stimulant with a reduced abuse liability, is described. This approach effectively prepares modafinil on a multigram scale in several steps from benzhydrol. The described synthetic route has also been used to produce the more water soluble analogue, adrafinil. X-ray crystallographic analysis on (-)-(diphenylmethanesulfinyl)acetic acid has determined the absolute configuration to be R.
63547-13-7 Process route
-
- 63547-44-4
2-benzhydrylsulfanyl-N-hydroxyacetamide
-
- 63547-13-7
adrafinil
| Conditions | Yield |
|---|---|
|
With dihydrogen peroxide; acetic acid; at 40 ℃;
|
72% |
-
- 91-01-0
1,1-Diphenylmethanol
-
- 63547-13-7
adrafinil
| Conditions | Yield |
|---|---|
|
Multi-step reaction with 4 steps
1: 99 percent / trifluoroacetic acid / 3 h / 20 °C
2: 99 percent / H2SO4 / Heating
3: 92 percent / hydroxylamine hydrochloride; KOH / methanol / 0.25 h
4: 72 percent / aq. H2O2; acetic acid / 40 °C
With potassium hydroxide; sulfuric acid; hydroxylamine hydrochloride; dihydrogen peroxide; acetic acid; trifluoroacetic acid; In methanol;
|
63547-13-7 Upstream products
-
63547-44-4
2-benzhydrylsulfanyl-N-hydroxyacetamide
-
91-01-0
1,1-Diphenylmethanol
-
63547-22-8
(benzhydrylthio)acetic acid
-
63547-23-9
(diphenylmethyl)(ethyl acetate)sulfide
Relevant Products
-
Sparteine sulfate anhydrousCAS：299-39-8
-
2,2'-DipyridylCAS：366-18-7
-
SildenafilCAS：139755-83-2
