94-09-7
- Product Name:Benzoicacid, 4-amino-, ethyl ester
- Molecular Formula:C9H11NO2
- Purity:99%
- Molecular Weight:
Product Details
Appearance:white odourless crystals
Benzocaine factory 94-09-7 Wholesaler with reasonable price
- Molecular Formula:C9H11NO2
- Molecular Weight:165.192
- Appearance/Colour:white odourless crystals
- Vapor Pressure:0.000589mmHg at 25°C
- Melting Point:88-90 °C
- Refractive Index:1.5600 (estimate)
- Boiling Point:310.7 °C at 760 mmHg
- PKA:2.5(at 25℃)
- Flash Point:164.2 °C
- PSA:52.32000
- Density:1.13 g/cm>3
- LogP:2.02670
Benzocaine 94-09-7 Usage
Benzocaine is a white odourless needle-like crystal, slightly soluble in water and easily soluble in organic solvents. For example: ethanol, chloroform, ether, soluble in almond oil, olive oil. Benzocaine is a local anaesthetic of the ester type with a poor solubility in water. The drug benzocaine is normally used as a topical pain reliever or as a common ingredient in cough drops. Benzocaine is used in multiple forms including lotion, gel, liquid, lozenges, and sprays. Benzocaine is a colorless trapezial crystal. Its melting point is 92℃ (88-90℃), boiling point is 183-184°C (1.87kPa). 1g of this drug is soluble in about 2500ml water, 5ml ethanol, 2ml chloroform, 4ml ether or 30-50ml almond oil and olive oil, and it is also soluble in dilute acid. Furthermore, being a PABA derivative, it has similar allergenic properties to procaine and is contraindicated with sulfonamide antibacterial agents.
Definition
ChEBI: Benzocaine cream or solution inside the condom de-sensitises the male sexual organ to help delay ejaculation and prolong erection during intercourse. Benzocaine is a benzoate ester having 4-aminobenzoic acid as the acid component and ethanol as the alcohol component. A surface anaesthetic, it is used to suppress the gag reflex, and as a lubricant and topical anaesthetic on the larynx, mouth, nasal cavity, respiratory tract, oesophagus, rectum, urinary tract, and vagina. It has a role as a topical anaesthetic, an antipruritic drug, an allergen and a sensitiser. It is a benzoate ester and a substituted aniline.
Safety Profile
Poison by ingestion and intraperitoneal routes. Human systemic effects by rectal route: methemoglobinemia/carboxyhemoglobinem ia in infants. A skin irritant and a mild sensitizer.
Structure and conformation
Ethyl aminobenzoate, a para-aminobenzoate derivative (PABA)
InChI:InChI=1/C9H11NO2/c1-2-12-9(11)7-3-5-8(10)6-4-7/h3-6H,2,10H2,1H3/p+1
94-09-7 Relevant articles
Metal-free organic dyes containing thiadiazole unit for dye-sensitized solar cells: A combined experimental and theoretical study
Siva Kumar, Gangala,Srinivas, Kola,Shanigaram, Balaiah,Bharath, Dyaga,Singh, Surya Prakash,Bhanuprakash,Rao, V. Jayathirtha,Islam, Ashraful,Han, Liyuan
, p. 13172 - 13181 (2014)
We have designed and synthesized four new metal free D-A-π-A type dyes (9-12) with variations in their acceptor/anchor groups. The dyes exhibited good power conversion efficiency ranging from 1.95-4.12%. Among the four dyes, 9 showed the best photovoltaic performance: short-circuit current density (Jsc) of 8.50 mA cm-2, open-circuit voltage (Voc) of 645 mV and fill factor (FF) of 0.75, corresponding to an overall conversion efficiency of 4.12% under standard global AM 1.5 solar light conditions. This journal is the Partner Organisations 2014.
Kinetics of the reduction of p-nitrobenzoic acid esters in nanoreactors on the basis of sulfonated polymers
Al'Tshuler,Shkurenko,Gorlov
, p. 372 - 375 (2015)
The kinetics of the reduction of p-nitrobenzoic acid esters in nanoreactors based on sulfonated network polymers containing nanodispersed palladium was studied. The kinetic characteristics of the hydrogenation of aromatic nitro compounds were calculated.
Cyclic (Alkyl)(amino)carbene Ligand-Promoted Nitro Deoxygenative Hydroboration with Chromium Catalysis: Scope, Mechanism, and Applications
Zhao, Lixing,Hu, Chenyang,Cong, Xuefeng,Deng, Gongda,Liu, Liu Leo,Luo, Meiming,Zeng, Xiaoming
, p. 1618 - 1629 (2021/01/25)
Transition metal catalysis that utilizes N-heterocyclic carbenes as noninnocent ligands in promoting transformations has not been well studied. The preparation of several commercially available pharmaceuticals by means of this strategy highlights its potential application in medicinal chemistry.
94-09-7 Process route
- 5798-75-4
Ethyl 4-bromobenzoate
- 7334-36-3
4,4'-triazenediyl-di-benzoic acid diethyl ester
- 47230-38-6
diethyl biphenyl-4,4'-dicarboxylate
- 53884-32-5
4,4'-Iminobis(benzoesaeureethylester)
- 94-09-7
p-aminoethylbenzoate
- 7250-68-2
4,4'-bis(ethoxycarbonyl)azobenzene
Conditions | Yield |
---|---|
With copper(l) iodide; sodium azide; N,N`-dimethylethylenediamine; In dimethyl sulfoxide; at 100 ℃; Inert atmosphere;
|
- 99-77-4
ethyl 4-nitrobenzoate
- 94-09-7
p-aminoethylbenzoate
- 7250-68-2
4,4'-bis(ethoxycarbonyl)azobenzene
- 6421-04-1,34241-38-8
4,4'-azoxy-di-benzoic acid diethyl ester
Conditions | Yield |
---|---|
With sodium tetrahydroborate; In tetrahydrofuran; water; at 20 ℃; for 3h; Catalytic behavior;
|
84 %Chromat. |
94-09-7 Upstream products
-
99-77-4
ethyl 4-nitrobenzoate
-
61273-18-5
4-nitro-benzoic acid-(2,2,2-trichloro-ethyl ester)
-
10367-96-1
2-(diethylamino)ethyl 2-chloro-4-nitrobenzoate
-
64-17-5
ethanol
94-09-7 Downstream products
-
15716-30-0
ethyl 4-
benzoate -
55966-68-2
ethyl 4-
benzoate -
99986-15-9
4-(2-mercapto-ethylamino)-benzoic acid ethyl ester
-
94-32-6
ethyl 4-(N-butylamino)benzoate
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